Long-term caloric restriction activates the myocardial SIRT1 AMPKPGC-1 pathway in C57BL6J male mice

Background: Caloric restriction (CR) can help in improving heart function. There is as yet no consen- sus on the mechanism of the effect of CR. Silent mating-type information regulation 1 (SIRT1), adenosine monophosphate-activated protein kinase (AMPK), and mTOR are key players in metabolic stress management. We aimed to explore the effect of CR on the myocardial SIRT1/AMPK/mTOR pathway in mice. Methods: Thirty-six 6-week-old male C57BL/6J mice were randomly divided into three groups: normal...