Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1SLC22A12), a renal re-absorber of urate

BRIEF COMMUNICATION OPEN Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber of urate Yu Toyoda 1,3 , Tappei Takada 1,3*, Hiroki Saito1,2,3 , Hiroshi Hirata2 , Ami Ota-Kontani 2 , Naoyuki Kobayashi 2 , Youichi Tsuchiya 2 and Hiroshi Suzuki 1 As hyperuricemia is a cause of urate-related diseases such as gout, the anti-hyperuricemic and/or uricosuric activity of food ingredients is receiving increased...