Matrix Interference Removal Using Fe3O4SiO2-PSA-Based Magnetic Dispersive Solid-Phase Extraction for UPLC-MSMS Analysis of Diazepam in Aquatic Products

A sensitive method was developed for detecting diazepam residues in aquatic products using magnetic dispersive solid-phase extraction (MDSPE) coupled with ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS). Samples extracted with 1% ammonia–acetonitrile were purified using synthesized Fe3O4@SiO2-PSA nanopar- ticles via MDSPE before UPLC-MS/MS analysis. Separation was performed on a C18 column with gradient elution using 0.1% formic acid–2 mM ammonium...