Protective effects of curcumin against chronic alcohol-induced liver injury in mice through modulating mitochondrial dysfunction and inhibiting endoplasmic reticulum stress

Background: Curcumin is a major active ingredient extracted from powdered dry rhizome of Curcuma longa. In Ayurveda and traditional Chinese medicine, it has been used as a hepatoprotective agent for centuries. However, the underlying mechanisms are not clear. Objective: The present study is to investigate the hepatoprotective effects of curcumin in chronic alcohol-in- duced liver injury and explore its mechanism. Design: Alcohol-exposed Balb/c mice were treated with curcumin (75 and 150 mg/kg)...