Mechanistic Elucidation of the Anti-Ageing Effects of Dendrobium officinale via Network Pharmacology and Experimental Validation

Dendrobium officinale (Orchidaceae) is a commonly used medicinal and edible herb. Al‑ though its anti‑ageing properties have been demonstrated, the underlying mechanisms remain unclear. We employed network pharmacology and molecular biology techniques to systematically explore its anti‑ageing mechanisms. An ageing model was established using D‑galactose‑induced Kunming mice. D. officinale significantly ameliorated ageing‑ related symptoms, including behavioural impairment and organ index...