The Efficacy of ProsomnialTM Compared to a Synthetic Comparator for Melatonin Absorption and a Pilot for Sleep Efficacy —A Randomised, Double-Blind, Active-Controlled, Cross-Over Study

Background: Recent findings have identified pistachios as a rich source of plant-derived melatonin, prompting the development of ProsomnialTM , a unique natural melatonin supplement. This randomised, double-blind, active- controlled, cross-over pilot study aimed to evaluate the absorption and short- term effects on sleep of ProsomnialTM compared to synthetic melatonin. Methods: Twenty-six healthy adults (mean age 31.2 ± 7.5 years) with self-re- ported difficulty initiating sleep participated....