Simultaneous quantitation of multiple myeloma related dietary metabolites in serum using HILIC-LC-MSMS

Background: Recent studies from targeted and untargeted metabolomics have consistently revealed that diet-related metabolites, including carnitine (C0), several species of acylcarnitines (AcyCNs), amino acids, ceramides, and lysophosphatidylcholines (LPCs) may serve as potential multiple myeloma (MM) biomarkers. However, most of these approaches had some intrinsic limitations, namely low reproducibility and compro- mising the accuracy of the results. Objective: This study developed and...