Development of Conjugated Linoleic Acid Nanostructured Lipid Carriers and Their Synergistic Efficacy with Curcumin

Curcumin has good anti-cancer and antioxidant properties. However, the poor water solu- bility and low bioavailability limit its application in food products. This study constructed a nanostructured lipid carrier (Cur-CLA-NLC) encapsulating curcumin using conjugated linoleic acid (CLA) as the liquid lipid and stearic acid as the solid lipid. Cur-CLA-NLC exhibits significantly enhanced bioaccessibility, antioxidant activity, and cytocompatibility. CLA, as a liquid lipid in Cur-CLA-NLC, has a...