Research on the Genetic Polymorphism and Function of inlA with Premature Stop Codons in Listeria monocytogenes

Listeria monocytogenes is a Gram-positive bacterial species that causes listeriosis, a ma- jor foodborne disease worldwide. The virulence factor inlA facilitates the invasion of L. monocytogenes into intestinal epithelial cells expressing E-cadherin receptors. Naturally occurring premature stop codon (PMSC) mutations in inlA have been shown to result in the production of truncated proteins associated with attenuated virulence. Moreover, different L. monocytogenes strains contain distinct inlA...