Troxerutin alleviates kidney injury in rats via PI3KAKT pathway by enhancing MAP4 expression

Background: Troxerutin is a flavonoid compound and possesses potential anti-cancer, antioxidant, and an- ti-inflammatory activities. Besides, cisplatin is one of the most widely used therapeutic agents, but the clinical uses of cisplatin are often associated with multiple side effects, among which nephrotoxicity is more common. Objective and design: This study explored the protective effects of troxerutin (150 mg kg−1 day−1 for 14 days) against cisplatin-induced kidney injury and the potential...