Optimizing the Bioprocesses of Bacteriocin Production in Lacticaseibacillus paracasei HD1.7 by the Acetate Switch: Novel Insights into the Labor Division Between Energy Metabolism, Quorum Sensing, and Acetate

Acetate may act as a signaling molecule, regulating Paracin 1.7 production via quorum sensing (QS) in Lacticaseibacillus paracasei HD1.7. The “acetate switch” phenomenon re- quires mechanistic exploration to optimize Paracin 1.7 production. The “acetate switch” phenomenon delays with higher glucose levels (30 h, 36 h, and 96 h). Before the occur- rence of the “acetate switch”, the ATP content increases and peaks at the “acetate switch” point and the NAD+/NADH ratio decreases, indicating energy...