In-Silico and in vitro Studies Revealed that Rosmarinic Acid Inhibited Methanogenesis via Regulating Composition and Function of Rumen Microbiota

Inhibition of methyl-coenzyme M reductase can sup- press the activity of ruminal methanogens, thereby reducing enteric methane emissions of ruminants. How- ever, developing specific and environmentally friendly inhibitors is a challenging endeavor. To identify a natural and effective methane inhibitor that specifically targets methyl-coenzyme M reductase, molecular docking tech- nology was employed to screen a library of phytogenic compounds. A total of 52 candidate compounds were ob- tained...