Lactobacillus plantarum LP45 inhibits the RANKLOPG signaling pathway and prevents glucocorticoid-induced osteoporosis

Objective: To examine the potential effect of the probiotic strain Lactobacillus plantarum LP45 on osteoporo- sis and to explore the involved molecular mechanisms. Methods: A rat model of glucocorticoid-induced osteoporosis (GIO) was established, which was also orally administered with increasing doses of LP45 for 8 weeks. After the termination of the 8-week treatment, the tibia and femur bones of rats were analyzed for bone histomorphometry, bone mineral content (BMC), and bone mineral...