Inhibition of castration-resistant prostate cancer growth by genistein through suppression of AKR1C3

Background: Prostate cancer is the second leading cause of cancer-related death among males in America. The patients’ survival time is significantly reduced after prostate cancer develops into castration-resistant prostate cancer (CRPC). It has been reported that AKR1C3 is involved in this progression, and that its abnormal expression is directly correlated with the degree of CRPC malignancy. Genistein is one of the active com- ponents of soy isoflavones, and many studies have suggested that...