Chukrasia tabularis limonoid plays anti-inflammatory role by regulating NF- B signaling pathway in lipopolysaccharide-induced macrophages

Background: Chukrasia tabularisis, a well-known tropical tree native to southeastern China, has anti-inflam- matory and antioxidant activities, and contains large amounts of limonoids and triterpenoids. Objective: The aim of this study was to investigate the potential anti-inflammatory activity of limonoids from C. tabularis on lipopolysaccharide (LPS)-mediated RAW264.7 cells. Methods and results: Using a bioassay-guided approach, the chemical fraction with high anti-inflammatory activity was...