Ablation of the gut microbiota alleviates high-methionine diet-induced hyperhomocysteinemia and glucose intolerance in mice

ARTICLE OPEN Ablation of the gut microbiota alleviates high-methionine diet-induced hyperhomocysteinemia and glucose intolerance in mice Wenqiang Li1,2 , Yiting Jia 1,2 , Ze Gong 1,2 , Zhao Dong 1,2 , Fang Yu 1,2 , Yi Fu 1,2 , Changtao Jiang1,2,3,4 ✉ and Wei Kong 1,2 ✉ A high-methionine (HM) diet leads to hyperhomocysteinemia (HHcy), while gastrointestinal tissue is an important site of net homocysteine (Hcy) production. However, the role of the gut microbiota in host HHcy remains obscure....