Study on the Calcium Transport-Promoting Property and Mechanism of the Peptide–Calcium Complex DEEENDQVK–Ca Based on a Caco-2 Monolayer Model

Peptide–calcium complexes exhibit promise as calcium supplements due to their enhanced bioavailability. Phosvitin nonapeptide DEEENDQVK (DK) possesses a high calcium- binding capability. This study investigated the calcium transport-promoting properties of DK and DEEENDQVK–calcium complex (DK–Ca) using a Caco-2 monolayer model. Both DK and DK–Ca concentration-dependently promoted calcium transport, and compared with the CaCl2 control, enhanced calcium transport by 1.07-fold and 1.83-fold,...