Machine Learning and UHPLC–MSMS-Based Discrimination of the Geographical Origin of Dendrobium officinale from Yunnan, China

A rapid targeted screening method for 22 compounds, including flavonoids, glycosides, and phenolics, in Dendrobium officinale was developed using UHPLC–MS/MS, demonstrat- ing good linear correlation coefficients, precision, repeatability, and stability. D. officinale from the Guangnan and Maguan regions can be effectively classified into two distinct categories using PCA. In addition, OPLS-DA discriminant analysis enables clear sepa- ration between groups, with samples forming well-defined...