Antcin K inhibits VCAM-1-dependent monocyte adhesion in human rheumatoid arthritis synovial fibroblasts

Background: Antcin K, an extract of Antrodia cinnamomea (a medicinal mushroom endemic to Taiwan com- monly used in Chinese medicine preparations), inhibits proinflammatory cytokine production and angiogen- esis in human rheumatoid arthritis synovial fibroblasts (RASFs), major players in RA disease. Antcin K also inhibits disease activity in mice with collagen-induced arthritis (CIA). Up until now, the effects of Antcin K upon cell adhesion molecules (CAMs) were unknown. Methods: RA and healthy...