Acute Metabolic and Neurocognitive Adaptations to Short-Term Fasting

This study examined the metabolic, cognitive, and electrophysiological adap- tations to a 48-hour water-only fast in a cohort of adults (n = 10). Blood glu- cose, β-hydroxybutyrate (BHB), Trail Making Test A (TMTA) and B (TMTB) performance, and auditory P300 event-related potentials were measured at baseline, 24 hours, and 48 hours. Glucose decreased progressively from 104.5 ± 10.2 mg/dL at baseline to 69.2 ± 7.9 mg/dL at 48 h (−34%), while BHB rose from 0.27 ± 0.15 mmol/L to 2.73 ± 0.81...