Stigmasterol attenuates hepatic steatosis in rats by strengthening the intestinal barrier and improving bile acid metabolism

ARTICLE OPEN Stigmasterol attenuates hepatic steatosis in rats by strengthening the intestinal barrier and improving bile acid metabolism Yaxin Zhang 1,2 , Yuyan Gu 1 , Jing Jiang 3 , Xiaobing Cui 4 , Saibo Cheng 3 , Linling Liu3 , Zhiyong Huang 5 , Rongxin Liao 6 , Peng Zhao 6 , Jieying Yu 3 , Jing Wang 3 , Yuhua Jia3 ✉, Wen Jin 7 ✉ and Fenghua Zhou 2,3 ✉ Stigmasterol (ST) has been shown to improve both lipid and bile acid (BA) metabolism. However, the mechanism(s) by which ST prevents...