Circadian dysregulation disrupts gut microbe-related bile acid metabolism

Background: Disturbance of circadian rhythm leads to abnormalities in bile acid (BA) and lipid metabolism, and it is of great significance to explore the relationship between them. This study explored the effects of cir- cadian dysregulation on the rhythms of intestinal BA metabolism. Method: Period circadian clock 1/period circadian clock 2 (Per1/Per2) double gene knockout (DKO) and wild- type (WT) male C57BL/6 mice were fed with a control or high-fat diet for 16 weeks. We measure plasma...