Effects of N-Acetylmannosamine (ManNAc) on Cognitive and Psychological Function in Middle-Aged and Older Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial

Background: To delay the onset of dementia with age, it is important for healthy adults to take preventive measures before cognitive decline occurs. Cognitive function decline is often associated with mood disorders such as depression. N-acetylmannosamine (ManNAc) showed activity in a screening assay for com- ponents that induced the generation of orexin-producing neurons. Orexins are neuropeptides involved in the regulation of various bodily functions, such as cognitive and psychological...