Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway

ARTICLE OPEN Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway So Yamamoto 1 , Tomoko Kayama1 , Moeko Noguchi-Shinohara 2 , Tsuyoshi Hamaguchi2 , Masahito Yamada 2 , Keiko Abe 3,4 and Shoko Kobayashi 1 ✉ Rosmarinic acid (RA), a polyphenol found in Lamiaceae herbs, is a candidate of preventive ingredients against Alzheimer’s disease (AD) as it potently suppresses the aggregation of amyloid β (Aβ); however, the effect of RA on tau...