The PPARCYP4A14 bile acid pathway is associated with lipid metabolism disorders caused by low birth weight with high-fat diet

Purpose: To investigate possible mechanisms underlying the greater susceptibility of lipid metabolism disor- ders in low birth weight (LBW) mice fed with high-fat diets (HFDs). Methods: LBW mice model was established by using the pregnancy malnutrition method. Male pups were selected from LBW and normal-birth weight (NBW) offspring at random. After 3 weeks of weaning, all offspring mice were fed with HFD. Serum triglycerides (TGs), cholesterol (TC), low density lipoprotein (LDL-C), total bile...