The Efficacy of Hesperidin in the Reduction of Atherosclerosis in ApoE-- Mice and Its Possible Mechanism of Action

Atherosclerosis (AS) currently lacks fully effective treatments. This study investigated the natural compound hesperidin as a potential therapy. Apolipoprotein E knockout (ApoE−/−) mice were used as a model of atherosclerosis; we found that hesperidin treat- ment improved physiological and metabolic health, reduced plaque formation, and de- creased systemic inflammation and oxidative stress. Hesperidin also reshaped gut micro- biota, increasing beneficial bacteria (Verrucomicrobia and...