Capsaicin has an anti-obesity effect through alterations in gut microbiota populations and short-chain fatty acid concentrations

Background: Capsaicin (CAP) has an anti-obesity effect that has been shown to involve the transient receptor potential vanilloid-1 (TRPV1) channel. Importantly, recent studies in high fat diet (HFD)-fed mice show that CAP also alters gut microbiota composition and causes weight loss in HFD-fed mice. Many studies have suggested that short-chain fatty acids (SCFAs) mediate the links between diet, gut microbiota, and fat storage. Objective: The present study investigated whether CAP exerted its...