Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites

ARTICLE OPEN Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites Yasuaki Kabe 1,2,6 ✉, Daisuke Takemoto 1,3,6 , Ayaka Kanai 1 , Miwa Hirai 1 , Yoshiko Ono 3 , Sota Akazawa 3 , Manabu Horikawa 4 , Yoshinori Kitagawa 3 , Hiroshi Handa 5 , Tomohiro Rogi 3 ✉, Hiroshi Shibata 3 and Makoto Suematsu 1 ✉ Sesamin [(7α,7′α,8α,8′α)-3,4:3′,4′-bis(methylenedioxy)-7,9′:7′,9-diepoxylignane] is a major lignan in sesame seeds. Sesamin is converted to the catechol metabolite, SC1...