High hydrostatic pressure extract of mulberry leaves ameliorates hypercholesterolemia via modulating hepatic microRNA-33 expression and AMPK activity in high cholesterol diet fed rats

Background: Mulberry leaf (Morus alba L.) contains multiple bioactive ingredients and has been used in the treatment of obesity, diabetes, inflammation, and atherosclerosis. High hydrostatic pressure (HHP) pro- cessing has been developed for the extraction of bioactive compounds from plants. However, the hypocho- lesterolemic effect of the HHP extract from mulberry leaves and its underlying mechanism have never been investigated. Objective: The specific aim of the present study was to...