Interactions Between HEP Peptide and EGFR Involved in the Osteoblast Differentiation

The epidermal growth factor receptor (EGFR), as an important target protein for inhibit- ing and intervening in osteoporosis, is associated with cell migration, proliferation, and apoptosis. Peptides derived from food have been shown to have a strong affinity for EGFR, thereby regulating downstream cellular-signaling pathways and participating in stimulating bone formation. However, it is still a “black box” as to how active peptides affect the conformational changes in the EGFR-binding domain...