Suppressive effect of glycyrrhizic acid against lipopolysaccharide- induced neuroinflammation and cognitive impairment in C57 mice via toll-like receptor 4 signaling pathway

Background: Glycyrrhizinic acid (GA), a major active ingredient enriched in the roots of licorice, possesses well-confirmed anti-inflammatory effects. Objective: To evaluate the underlying mechanisms of GA against lipopolysaccharide (LPS)-induced chronic neuroinflammation and memory impairment. Design: We explored to investigate the effects of GA on neuroinflammation and memory impairment in an LPS-induced Alzheimer’s mouse model. Results: Data of micro-PET/CT imaging and morris water maze...