Proanthocyanidins-Rich Euterpe oleracea Mart Seed Extract Prevents Vascular and Perivascular Adipose Tissue Remodeling by Regulating the Renin-Angiotensin System, Inflammation, and Oxidative Damage in Diet-Induced Obese Mice

Ectopic excessive fat deposition, including the perivascular adipose tissue (PVAT), may negatively influence vascular homeostasis and has emerged as a target for treating obesity-related vascular disease. The açaí ( Euterpe oleracea Mart) seed extract (ASE) has beneficial metabolic effects, which could reduce the risk of obesity-related vascular disease. Therefore, this study aimed to in- vestigate the impact of treatment with ASE on aorta remodeling and hyper- tension and evaluate its...