Dietary lactoferrin has differential effects on gut microbiota in young versus middle-aged APPswePS1dE9 transgenic mice but no effects on cognitive function

Background: Existing evidence suggest that lactoferrin might be beneficial for Alzheimer’s disease, while pre- cise mechanisms are not fully elucidated. Objective: To determine the effects of lactoferrin intervention on cognitive function from APPswe/PS1dE9 (APP/PS1) mice, and potential mechanisms involved. Design: Both the young and middle-aged male APP/PS1 mice were divided into the control and lactoferrin intervention groups with 16 weeks’ intervention. Results: Lactoferrin had no effects...