Genistein prevents bone loss in type 2 diabetic rats induced by streptozotocin

Background: Diabetic osteoporosis has become a severe public health problem in the aging societies. Genistein has been reported to play an important role in preventing and treating metabolic diseases via its anti- inflammatory, antioxidant, anti-estrogenic, and estrogen-like functions. Objective: We aimed to investigate whether genistein exerts bone-protective effect on diabetic rats induced by 35 mg/kg streptozotocin (STZ) plus a 4-week high-fat diet. Design: Sprague–Dawley rats were randomly...