Diallyl trisulfide induces pro-apoptotic autophagy via the AMPK SIRT1 signalling pathway in human hepatocellular carcinoma HepG2 cell line

Background: Liver cancer is associated with a high mortality rate worldwide. Hepatocellular carcinoma (HCC) constitutes a large proportion of primary liver cancers, and most of its alterations currently remain untreat- able. Diallyl trisulfide (DATS), the main chemical constituent of allicin, affects tumour development by regu- lating cell apoptosis. Allicin-induced autophagy could contribute to apoptosis in HepG2 cells. We rigorously examined the autophagy-related mechanism of allicin-induced...