In vitro and in silico characterization of adiponectin-receptor agonist dipeptides

ARTICLE OPEN In vitro and in silico characterization of adiponectin-receptor agonist dipeptides Yuna Lee 1 , Akihiro Nakano 1 , Saya Nakamura 1 , Kenta Sakai 2 , Mitsuru Tanaka 2 , Keisuke Sanematsu 2,3,4 , Noriatsu Shigemura 2,3 and Toshiro Matsui 1,2 ✉ The aim of this study is to develop a dipeptide showing an adiponectin receptor 1 (AdipoR1) agonistic effect in skeletal muscle L6 myotubes. Based on the structure of the AdipoR1 agonist, AdipoRon, 15 synthetic dipeptides were targeted to...