Rational design of hyperstable antibacterial peptides for food preservation

ARTICLE OPEN Rational design of hyperstable antibacterial peptides for food preservation Yashavantha L. Vishweshwaraiah 1,4 , Abhishek Acharya 1,4 , Vinayak Hegde 1,2 and Balaji Prakash 1,3 ✉ We describe the design of peptides with properties like thermostability, pH stability, and antibacterial activity against a few bacterial food pathogens. Insights obtained from classical structure-function analysis of natural peptides and their mutants through antimicrobial and enzymatic assays are used...